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Anti-Diarrhea treatment with Voacanga



Diarrhea is a condition where a person passes loose and watery bowel movements. 

It is commonly caused by viral, bacterial, or parasitic infections, but it can also be brought on as a side effect of certain medicines. Diarrhea is mostly a mild disorder that clears up on its own in several days. 

However, if you have severe diarrhea (7 to 10 loose stools within 24 hours) it’s important to see your doctor right away because this may be an indication of something more serious such as infection with Salmonella typhi or Vibrio cholera bacteria or amoeba Entamoeba histolytica parasite).


Table of Contents

Common causes of diarrhea include

There are several types of diarrhea, including:


Food poisoning

The most common cause of acute diarrhea is toxin-producing bacteria or viruses in food or water.



Exposure to environmental toxins such as cleaning chemicals can also cause acute diarrhea.



A food allergy or an allergic reaction to a medication may trigger diarrhea (or vomiting). 

In severe cases, it can lead to anaphylaxis (a life-threatening condition) if not treated promptly with epinephrine (adrenaline).


Dietary changes

Some people who eat too many fiber-rich foods like fruits and vegetables experience diarrhea because their systems aren’t accustomed yet to this type of diet change; 

in addition, fiber can irritate the digestive tract leading up towards the large intestine where most cases happen clinically speaking if left untreated long enough without proper care taken before symptoms start showing up on regular basis during routine daily activities.

Just like going about one’s normal routine without any problems whatsoever which usually means everything seems fine except for slight discomfort caused by something else entirely unrelated like having too much stress at work lately causing you not being able do anything else.

However, just sit there staring blankly into space while hoping everyone else would leave so then you could go home early today after all we did finish our work yesterday so technically speaking there shouldn’t be any reason why anyone wouldn’t want me leaving now right away.


How does Ebola Cause Diarrhea?

The Ebola virus causes viral hemorrhagic fever. The symptoms are similar to other types of viral hemorrhagic fever, but they are more severe. Symptoms include:

  • Fever
  • Headache
  • Muscle pain and joint pain
  • Fatigue, weakness, or exhaustion

If you have these symptoms, you should contact your healthcare provider about them immediately.


Voacanga africana (Rubiaceae)

Voacanga Africana (Rubiaceae) is a plant native to the tropical forests of West Africa. 

Voacanga Africana has been used in traditional medicine for centuries, and various names including African dream root, timba, and Chamba know it. 

The plant can be found as a shrub or small tree that grows up to 10 feet high and produces red flowers with yellow centers.

The anti-diarrheal effects of Voacanga Africana have been studied extensively, but most studies have focused on animals such as rats rather than humans. 

In one study involving human subjects who self-reported having diarrhea, taking an extract made from Voacanga Africana twice daily caused significant improvements in symptoms (such as time spent having diarrhea) after three days compared with no treatment over the same period.


Phytochemical composition of Voacanga Africana

The major phytochemicals found in Voacanga Africana are L-tryptophan, L-tyrosine, L-phenylalanine, L-arginine, and histidine.

L-tryptophan is a precursor of serotonin (5-hydroxytryptamine; 5HT), a monoamine neurotransmitter that regulates mood and appetite. 

Serotonin also plays a role in sleep regulation, cognitive function, and pain perception. 

It has been suggested that certain foods can increase the production of serotonin which may aid in relieving depression symptoms such as fatigue, irritability, or lack of concentration. 

These foods include milk products like yogurt or cheese; fish like tuna or mackerel; beef such as steak; turkey etc., nuts like almonds or walnuts, etc., beans such as black beans, etc., and bananas, etc.


How does Voacanga treat Diarrhea?

Diarrhea is a common digestive disorder that is characterized by the passage of loose or watery stools. 

It is usually caused by viral, bacterial, and parasitic infections as well as dietary indiscretions such as eating too much spicy food.

Voacangine inhibits the intestinal secretion of water into the intestines by closing potassium channels. 

This causes dehydration and reduces stool output, so it’s thought to have some effect on reducing symptoms of diarrhea.

A study published in the Journal of Ethnopharmacology examined the anti-diarrheal activity of Voacanga Africana in rats with the administration of about 30g/kg body weight for 7 days each week for four weeks. 

This dose corresponded to 32 times higher than that found in a typical single dose ingested by humans, suggesting it could be effective at preventing or treating acute episodes or reducing their severity while also reducing inflammation associated with colitis symptoms such as abdominal pain and bloody stools.

And current research on animals seems to support this claim. The plant contains many active ingredients that have been shown to work as anti-diarrheal treatments, including:

  • Voacangine
  • Vomifoliol
  • Vomifolin F
  • Coumarins.


How does voacangine act in the body?

Voatangine is a non-opioid, non-sedative anti-diarrhea medication. It’s made from the root extract of the African tree Voacanga Africana.

To understand how it works, you have to understand how your body regulates bowel movements. 

If you eat too much food or experience stress, your colon can’t process all of it at once, which causes waste to get backed up in your intestines and lead to constipation or diarrhea. 

Voatangine works by stimulating dopamine receptors in the gut wall that help control its contractions and peristalsis (the wave-like motion that moves food through your digestive tract). 

This helps with digestion by sending more water into your intestines so they can absorb more nutrients from what you eat more easily. 

Voacangine may also be more effective than loperamide or metronidazole for treating watery stool, a common symptom of travelers’ diarrhea.


Can voacangine cause side effects?

Voacangine can cause side effects, but they’re uncommon and usually mild. Some people experience nausea and vomiting, dizziness, headache, or muscle twitching. 

These symptoms usually disappear after the first few days of taking voacangine.

People who abuse drugs or have a history of mental illness may be more likely to experience these effects if they take it for diarrhea. 

Other medications like antipsychotics are often used with voacangine to reduce these side effects in people with a history of drug abuse or mental illness.


There is an urgent need for treatment to combat the disease, utilizing any means available.

Voacangine is an anti-diarrhea treatment isolated from the African tree Voacanga africana. 

As a drug, voacangine is used to treat diarrhea and prevent it in people taking certain medicines that cause diarrhea (e.g., cancer chemotherapy). 

It contains several active compounds that have been shown to reduce diarrhea by inhibiting the activity of certain enzymes, which may help prevent the movement of bacteria through intestinal walls into blood vessels causing inflammation and tissue damage.

Amid the Ebola outbreak in Liberia, Sierra Leone, and Guinea, there is an urgent need for treatment to combat the disease, utilizing any means available. 

The virus has killed more than 11,000 people in West Africa and shows no signs of slowing down. 

While many organizations are working to develop a vaccine or cure for this deadly virus, effective anti-diarrhea treatment would be a welcome relief for those suffering from diarrhea due to Ebola.

The Ebola virus is spread through bodily fluids including blood, vomit, and diarrhea; 

therefore, it can easily be contracted by coming into contact with infected materials or bodily fluids of someone who is infected with Ebola without proper protection (such as gloves). 

People are dying from diarrhea caused by this deadly virus. There are no vaccines or treatments yet; however, researchers recently discovered that using Voacanga Africana bark powder can reduce the severity of symptoms associated with severe diarrhea caused by enteric viruses such as rotavirus and coronavirus.



The current study shows that Voacanga Africana (Rubiaceae) has anti-diarrheal properties and can be used to treat diarrhea in patients suffering from Ebola virus disease (EVD). 

There is an urgent need for treatment to combat the disease, utilizing any means available. 

In conclusion, it would be appropriate to note that there are many other plants found in Africa that have similar biological activities and may also be helpful as anti-diarrheal agents.


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